Preservation of paraoxenase activity by wine flavonoids - Possible role in protection of LDL from lipid peroxidation

被引：47

作者：

Fuhrman, B ^{[1
]}

Aviram, M

机构：

[1] Rambam Med Ctr, Lipid Res Lab, IL-31096 Haifa, Israel

[2] Technion, Fac Med, Rappaport Family Inst Res Med Sci, Lipid Res Lab, Haifa, Israel

来源：

ALCOHOL AND WINE IN HEALTH AND DISEASE | 2002年 / 957卷

关键词：

red wine; flavonoids; polyphenols; antioxidants; paraoxonase; atherosclerosis;

D O I：

10.1111/j.1749-6632.2002.tb02933.x

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Paraoxonase is an esterase physically associated with HDL, and its activity has been shown to be inversely related to the risk of cardiovascular diseases. We have shown that paraoxonase can hydrolyze specific lipid peroxides in oxidized lipoproteins and in atherosclerotic lesions. Paroxonase was shown to be inactivated by oxidative stress. Consumption of wine flavonoids was shown to preserve paraoxonase activity by reducing the oxidative stress in apolipoprotein E-deficient mice, thereby contributing to paraoxonase hydrolytic activity on lipid peroxides in oxidized lipoproteins and atherosclerotic lesions.

引用

页码：321 / 324

页数：4

共 13 条

[1] Does paraoxonase play a role in susceptibility to cardiovascular disease?
Aviram, M
[J]. MOLECULAR MEDICINE TODAY, 1999, 5 (09): : 381 - 386
[2] Human serum paraoxonases (PON1) Q and R selectively decrease lipid peroxides in human coronary and carotid atherosclerotic lesions - PON1 esterase and peroxidase-like activities
Aviram, M
Hardak, E
Vaya, J
Mahmood, S
Milo, S
Hoffman, A
Billicke, S
Draganov, D
Rosenblat, M
[J]. CIRCULATION, 2000, 101 (21) : 2510 - 2517
[3] Paraoxonase active site required for protection against LDL oxidation involves its free sulfhydryl group and is different from that required for its arylesterase/paraoxonase activities - Selective action of human paraoxonase allozymes Q and R
Aviram, M
Billecke, S
Sorenson, R
Bisgaier, C
Newton, R
Rosenblat, M
Erogul, J
Hsu, C
Dunlop, C
La Du, B
[J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1998, 18 (10) : 1617 - 1624
[4] Human serum paraoxonase (PON 1) is inactivated by oxidized low density lipoprotein and preserved by antioxidants
Aviram, M
Rosenblat, M
Billecke, S
Erogul, J
Sorenson, R
Bisgaier, CL
Newton, RS
La Du, B
[J]. FREE RADICAL BIOLOGY AND MEDICINE, 1999, 26 (7-8) : 892 - 904
[5] Paraoxonase inhibits high-density lipoprotein oxidation and preserves its functions - A possible peroxidative role for paraoxonase
Aviram, M
Rosenblat, M
Bisgaier, CL
Newton, RS
Primo-Parmo, SL
La Du, BN
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1998, 101 (08) : 1581 - 1590
[6] Polyphenolic flavonoids inhibit macrophage-mediated oxidation of LDL and attenuate atherogenesis
Aviram, M
Fuhrman, B
[J]. ATHEROSCLEROSIS, 1998, 137 : S45 - S50
[7] Aviram M, 2000, AM J CLIN NUTR, V71, P1062
[8] CONSUMPTION OF RED WINE WITH MEALS REDUCES THE SUSCEPTIBILITY OF HUMAN PLASMA AND LOW-DENSITY-LIPOPROTEIN TO LIPID-PEROXIDATION
FUHRMAN, B
LAVY, A
AVIRAM, M
[J]. AMERICAN JOURNAL OF CLINICAL NUTRITION, 1995, 61 (03) : 549 - 554
[9] Flavonoids protect LDL from oxidation and attenuate atherosclerosis
Fuhrman, B
Aviram, M
[J]. CURRENT OPINION IN LIPIDOLOGY, 2001, 12 (01) : 41 - 48
[10] Reduced progression of atherosclerosis in apolipoprotein E-deficient mice following consumption of red wine, or its polyphenols quercetin or catechin, is associated with reduced susceptibility of LDL to oxidation and aggregation
Hayek, T
Fuhrman, B
Vaya, J
Rosenblat, M
Belinky, P
Coleman, R
Elis, A
Aviram, M
[J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1997, 17 (11) : 2744 - 2752

← 1 2 →