Expression of nestin mRNA is a differentiation marker in thyroid tumors

被引：24

作者：

Yamada, Hiroya ^{[1
,2
]}

Takano, Toru ^{[1
]}

Ito, Yasuhiro ^{[3
]}

Matsuzuka, Fumio ^{[3
]}

Miya, Akihiro ^{[3
]}

Kobayashi, Kaoru ^{[3
]}

Yoshida, Hiroshi ^{[3
]}

Watanabe, Mikio ^{[2
]}

Iwatani, Yoshinori ^{[2
]}

Miyauchi, Akira ^{[3
]}

机构：

[1] Osaka Univ, Sch Med, Dept Lab Med, Osaka 5650871, Japan

[2] Osaka Univ, Grad Sch Med, Div Hlth Sci, Osaka 5650871, Japan

[3] Kuma Hosp, Chuo Ku, Kobe, Hyogo 6500011, Japan

来源：

CANCER LETTERS | 2009年 / 280卷 / 01期

关键词：

Nestin; Cancer stem cell; Anaplastic thyroid carcinoma; Thyroid transcription factor-1; Gene expression; INTERMEDIATE-FILAMENT NESTIN; FETAL CELL CARCINOGENESIS; QUANTITATIVE MEASUREMENT; ANAPLASTIC CARCINOMA; STEM-CELLS; TRANSCRIPTION; CANCER; THYROGLOBULIN; HYPOTHESIS; PAPILLARY;

D O I：

10.1016/j.canlet.2009.02.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Nestin is a maker that identifies stem cells in some adult tissues, and its expression is believed to relate to malignancy in cancer cells. In this study, we measured the expression levels of nestin mRNA in various kinds of thyroid tumor by the real-time quantitative reverse transcription-polymerase chain reaction. Unexpectedly, nestin mRNA was detected in almost all differentiated thyroid tumors and normal thyroid tissues, whereas extremely decreased expression was observed in anaplastic carcinomas, which are the most malignant of the thyroid follicular cell-derived tumors. These results suggest that nestin mRNA is a differentiation marker, and its expression does not relate to malignant characteristics in thyroid tumors. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：61 / 64

页数：4

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