Gastric mucosal injury induced by local ischemia-reperfusion in rats - Role of endogenous endothelin-1 and free radical

被引：30

作者：

Hassan, M

Kashimura, H

Matsumaru, K

Nakahara, A

Iwata, R

Hayashi, T

Muto, H

Tanaka, N

Goto, K

Fukutomi, H

机构：

[1] UNIV TSUKUBA,INST CLIN MED,DEPT INTERNAL MED,DIV GASTROENTEROL,TSUKUBA,IBARAKI 305,JAPAN

[2] UNIV TSUKUBA,DEPT PHARMACOL,TSUKUBA,IBARAKI 305,JAPAN

[3] HITACHI LTD,CHEM,PHARMACEUT RES LAB,HITACHI,IBARAKI 317,JAPAN

来源：

DIGESTIVE DISEASES AND SCIENCES | 1997年 / 42卷 / 07期

关键词：

local ischemia-reperfusion; gastric mucosal injury; endothelin-1; free radical;

D O I：

10.1023/A:1018829718952

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

We investigated the role of an endogenous vasoconstrictor peptide endothelin-l (ET-1) and free radicals in local gastric ischemia-reperfusion injury in rats. Local gastric ischemia was induced by clamping the left gastric artery for 15 min and reperfusion was done for 10-30 min in the presence of 150 mM exogenous HCl intragastrically. Local gastric ischemia and reperfusion resulted in significant macroscopic and microscopic gastric mucosal damage together with elevation of gastric tissue ET-1 concentration. Gastric tissue ET-1 was found to increase after 15 min of ischemia alone and also with 30 min of reperfusion. A novel nonpeptide endothelin receptor antagonist, bosentan, or a combination of radical scavengers (superoxide dismutase, catalase, and deferoxamine) both attenuated gastric mucosal injury. However, the greater protection observed with bosentan than with radical scavengers might reflect a preferential role of endothelin-1 in this type of injury.

引用

页码：1375 / 1380

页数：6

共 30 条

[1] POLYMORPHONUCLEAR LEUKOCYTE INFILTRATION INTO GASTRIC-MUCOSA AFTER ISCHEMIA-REPERFUSION [J].