Purine metabolism in HIV-1 virus-infected T lymphocyte population

被引：5

作者：

Carlucci, F

Tabucchi, A

Perrett, D

Pizzichini, M

Rosi, F

Pagani, R

Marinello, E

机构：

[1] IST BIOCHIM & ENZIMOL,I-53100 SIENA,ITALY

[2] UNIV LONDON ST BARTHOLOMEWS HOSP MED COLL,LONDON EC1A 7BE,ENGLAND

来源：

BIOMEDICINE & PHARMACOTHERAPY | 1996年 / 50卷 / 10期

关键词：

purine nucleotides; T lymphocytes; HIV virus;

D O I：

10.1016/S0753-3322(97)89283-9

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Purine nucleotide metabolism has been studied in T-lymphocyte population in healthy subjects and in AIDS bearing patients. Nucleotide content was determined by HPLC. The overall rate of purine nucleotide synthesis was measured following the incorporation of C-14-formate into the nucleotides of a T cell suspension. The authors discuss the results, which indicate interesting variations in nucleotide content and a lower nucleotide synthesis, determined by kinetic studies.

引用

收藏

页码：505 / 509

页数：5

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