Inferring the demographic history and rate of adaptive substitution in Drosophila

被引:239
作者
Li, Haipeng [1 ]
Stephan, Wolfgang [1 ]
机构
[1] Univ Munich, Sect Evolutionary Biol, Dept Biol 2, Martinsried, Germany
来源
PLOS GENETICS | 2006年 / 2卷 / 10期
关键词
D O I
10.1371/journal.pgen.0020166
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
An important goal of population genetics is to determine the forces that have shaped the pattern of genetic variation in natural populations. We developed a maximum likelihood method that allows us to infer demographic changes and detect recent positive selection ( selective sweeps) in populations of varying size from DNA polymorphism data. Applying this approach to single nucleotide polymorphism data at more than 250 noncoding loci on the X chromosome of Drosophila melanogaster from an ( ancestral) African population and a ( derived) European, we found that the African population expanded about 60,000 y ago and that the European population split off from the African lineage about 15,800 y ago, thereby suffering a severe population size bottleneck. We estimated that about 160 beneficial mutations ( with selection coefficients s between 0.05% and 0.5%) were fixed in the euchromatic portion of the X in the African population since population size expansion, and about 60 mutations (with s around 0.5%) in the diverging European lineage.
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收藏
页码:1580 / 1589
页数:10
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