Structural biology of the writers, readers, and erasers in mono- and poly(ADP-ribose) mediated signaling

被引：56

作者：

Karlberg, Tobias ^{[1
]}

Langelier, Marie-France ^{[2
]}

Pascal, John M. ^{[2
]}

Schuler, Hervvig ^{[1
]}

机构：

[1] Karolinska Inst, Dept Med Biochem & Biophys, S-17177 Stockholm, Sweden

[2] Thomas Jefferson Univ, Kimmel Canc Ctr, Dept Biochem & Mol Biol, Philadelphia, PA 19107 USA

来源：

MOLECULAR ASPECTS OF MEDICINE | 2013年 / 34卷 / 06期

基金：

瑞典研究理事会;

关键词：

ADP-ribosylation; DNA repair; Glycohydrolase; Macro domain; Signaling pathways; Transferase; APOPTOSIS-INDUCING FACTOR; REPEAT-BINDING FACTOR-1; STERILE ALPHA-MOTIF; CRYSTAL-STRUCTURE; ADP-RIBOSE; NAD(+)-DEPENDENT DEACETYLASE; CATALYTIC FRAGMENT; SUBSTRATE-BINDING; CONSERVED DOMAIN; PROTEIN-KINASE;

D O I：

10.1016/j.mam.2013.02.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

ADP-ribosylation of proteins regulates protein activities in various processes including transcription control, chromatin organization, organelle assembly, protein degradation, and DNA repair. Modulating the proteins involved in the metabolism of ADP-ribosylation can have therapeutic benefits in various disease states. Protein crystal structures can help understand the biological functions, facilitate detailed analysis of single residues, as well as provide a basis for development of small molecule effectors. Here we review recent advances in our understanding of the structural biology of the writers, readers, and erasers of ADP-ribosylation. (C) 2013 Elsevier Ltd. All rights reserved.

引用

收藏

页码：1088 / 1108

页数：21

相关论文

共 130 条

[1] Poly(ADP-ribose)-Dependent Regulation of DNA Repair by the Chromatin Remodeling Enzyme ALC1 [J].

Ahel, Dragana ;

Horejsi, Zuzana ;

Wiechens, Nicola ;

Polo, Sophie E. ;

Garcia-Wilson, Elisa ;

Ahel, Ivan ;

Flynn, Helen ;

Skehel, Mark ;

West, Stephen C. ;

Jackson, Stephen P. ;

Owen-Hughes, Tom ;

Boulton, Simon J. .

SCIENCE, 2009, 325 (5945) :1240-1243

[2] Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins [J].

Ahel, Ivan ;

Ahel, Dragana ;

Matsusaka, Takahiro ;

Clark, Allison J. ;

Pines, Jonathon ;

Boulton, Simon J. ;

West, Stephen C. .

NATURE, 2008, 451 (7174) :81-U12

[3] Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase [J].

Ahuja, Nidhi ;

Schwer, Bjoern ;

Carobbio, Stefania ;

Waltregny, David ;

North, Brian J. ;

Castronovo, Vincenzo ;

Maechler, Pierre ;

Verdin, Eric .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (46) :33583-33592

[4] The zinc-finger domains of PARP1 cooperate to recognize DNA strand breaks [J].

Ali, Ammar A. E. ;

Timinszky, Gyula ;

Arribas-Bosacoma, Raquel ;

Kozlowski, Marek ;

Hassa, Paul O. ;

Hassler, Markus ;

Ladurner, Andreas G. ;

Pearl, Laurence H. ;

Oliver, Antony W. .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2012, 19 (07) :685-+

[5] The crystal structure of AF1521 a protein from Archaeoglobus fulgidus with homology to the non-histone domain of MacroH2A [J].

Allen, MD ;

Buckle, AM ;

Cordell, SC ;

Löwe, J ;

Bycroft, M .

JOURNAL OF MOLECULAR BIOLOGY, 2003, 330 (03) :503-511

[6] Molecular mechanism of poly(ADP-ribosyl)ation by PARP1 and identification of lysine residues as ADP-ribose acceptor sites [J].

Altmeyer, Matthias ;

Messner, Simon ;

Hassa, Paul O. ;

Fey, Monika ;

Hottiger, Michael O. .

NUCLEIC ACIDS RESEARCH, 2009, 37 (11) :3723-3738

[7] Discovery of Ligands for ADP-Ribosyltransferases via Docking-Based Virtual Screening [J].

Andersson, C. David ;

Karlberg, Tobias ;

Ekblad, Torun ;

Lindgren, Anders E. G. ;

Thorsell, Ann-Gerd ;

Spjut, Sara ;

Uciechowska, Urszula ;

Niemiec, Moritz S. ;

Wittung-Stafshede, Pernilla ;

Weigelt, Johan ;

Elofsson, Mikael ;

Schuler, Herwig ;

Linusson, Anna .

JOURNAL OF MEDICINAL CHEMISTRY, 2012, 55 (17) :7706-7718

[8] Iduna protects the brain from glutamate excitotoxicity and stroke by interfering with poly(ADP-ribose) polymer-induced cell death [J].

Andrabi, Shaida A. ;

Kang, Ho Chul ;

Haince, Jean-Francois ;

Lee, Yun-Il ;

Zhang, Jian ;

Chi, Zhikai ;

West, Andrew B. ;

Koehler, Raymond C. ;

Poirier, Guy G. ;

Dawson, Ted M. ;

Dawson, Valina L. .

NATURE MEDICINE, 2011, 17 (06) :692-U82

[9] Crystal structure of diphtheria toxin bound to nicotinamide adenine dinucleotide [J].

Bell, CE ;

Eisenberg, D .

BIOCHEMISTRY, 1996, 35 (04) :1137-1149

[10] Mechanism of ADP-ribosylation removal revealed by the structure and ligand complexes of the dimanganese mono-ADP-ribosylhydrolase DraG [J].

Berthold, Catrine L. ;

Wang, He ;

Nordlund, Stefan ;

Hogbom, Martin .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (34) :14247-14252

← 1 2 3 4 5 6 7 8 9 10 →