Autophagy and p70S6 kinase

被引：106

作者：

Klionsky, Daniel J.

Meijer, Alfred J.

Codogno, Patrice

Neufeld, Thomas P.

Scott, Ryon C.

机构：

[1] Univ Michigan, Inst Life Sci, Ann Arbor, MI 48109 USA

[2] Univ Amsterdam, Acad Med Ctr, Dept Biochem Med, NL-1105 AZ Amsterdam, Netherlands

[3] INSERM, U504, Villejuif, France

[4] Univ Minnesota, Dept Genet, Minneapolis, MN USA

来源：

AUTOPHAGY | 2005年 / 1卷 / 01期

关键词：

insulin receptor; lipid kinase; rapamycin; signaling; starvation; Tor;

D O I：

10.4161/auto.1.1.1536

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A paper by Scott et al.,(1) suggested that p70S6 kinase (p70S6k) is a positive regulatory factor for autophagy (Fig. 1). This finding is in contrast to previous data suggesting a negative role for this factor. The Scott et al. article was highlighted in Nature News & Views,2 which elicited a commentary by A.J. Meijer and P. Codogno. These authors present an alternate model for the role of p70S6k in autophagic induction, although still as a positive factor. Following the initial commentary is a response by TA Neufeld and R.C. Scott.

引用

收藏

页码：59 / 61

页数：3

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