EMT: When epithelial cells decide to become mesenchymal-like cells

被引：1191

作者：

Kalluri, Raghu ^{[1
,2
,3
]}

机构：

[1] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Matrix Biol, Boston, MA 02215 USA

[2] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA

[3] Harvard Mit Div Hlth Sci & Technol, Boston, MA USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2009年 / 119卷 / 06期

关键词：

TRANSITION; CANCER; PLASTICITY;

D O I：

10.1172/JCI39675

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Epithelial-mesenchymal transition (EMT) is critical for appropriate embryonic development, and this process is re-engaged in adults during wound healing, tissue regeneration, organ fibrosis, and cancer progression. Inflammation is a crucial conspirator in the emergence of EMT in adults but is absent during embryonic development. As highlighted in this Review series, EMT is now a recognized mechanism for dispersing cells in embryos, forming fibroblasts/mesenchymal cells in injured tissues, and initiating metastasis of epithelial cancer cells. Also discussed are proposals to classify EMT into three subtypes, each of which has different functional consequences.

引用

收藏

页码：1417 / 1419

页数：3

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