Fatty acid desaturation: variations on an oxidative theme

被引：54

作者：

Behrouzian, B

Buist, PH

机构：

[1] Maxygen Inc, Redwood City, CA 94063 USA

[2] Carleton Univ, Dept Chem, Ottawa, ON K1S 5B6, Canada

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2002年 / 6卷 / 05期

关键词：

D O I：

10.1016/S1367-5931(02)00365-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Significant progress in our understanding of the mechanism of fatty acid desaturation has been achieved. The site of initial oxidation has been determined for several membrane-bound desaturases and a common cryptoregiochemical theme has been revealed. The results of several studies, including a detailed analysis of a soluble plant desaturase system, point to a close mechanistic relationship between dehydrogenation and hydroxylation pathways.

引用

页码：577 / 582

页数：6

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