Functional human heme oxygenase has a neuroprotective effect on adult rat ganglion cells after pressure-induced ischemia

被引：33

作者：

Hegazy, KA ^{[1
]}

Dunn, MW ^{[1
]}

Sharma, SC ^{[1
]}

机构：

[1] New York Med Coll, Dept Ophthalmol, Valhalla, NY 10595 USA

来源：

NEUROREPORT | 2000年 / 11卷 / 06期

关键词：

adenoviral HHO-I; cell death; neuroprotection; recombinant adenovirus; retinal ganglion cells; transient ischemia;

D O I：

10.1097/00001756-200004270-00008

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Adult retina subjected to transient ischemia and reperfusion leads to controlled retinal ganglion cell (RGC) death over a period. Modification of intracellular mechanisms through a specific adenoviral vector containing the hemoxygenase gene (HO-1) provides avenues for RGC survival following HO-1 gene transfer and ischemia. RGC death rate was reduced by an average of 15% at 1, 2 and 3 weeks. A significant number of RGC transfected with functional HO-1 survived ischemic insults. Pharmacological stimulation of HO-1 may constitute a novel therapuetic approach to rescuing RGC experiencing ischemic/reperfusion injury. NeuroReport 11:1185-1189 (C) 2000 Lippincott Williams & Wilkins.

引用

页码：1185 / 1189

页数：5

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