Receptors, gephyrin and gephyrin-associated proteins: novel insights into the assembly of inhibitory postsynaptic membrane specializations

被引：134

作者：

Kneussel, M ^{[1
]}

Betz, H ^{[1
]}

机构：

[1] Max Planck Inst Brain Res, Dept Neurochem, D-60528 Frankfurt, Germany

来源：

JOURNAL OF PHYSIOLOGY-LONDON | 2000年 / 525卷 / 01期

关键词：

D O I：

10.1111/j.1469-7793.2000.t01-4-00001.x

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The synaptic localization of ion channel receptors is essential for efficient synaptic transmission and the precise regulation of diverse neuronal functions, such as signal integration and synaptic plasticity. Emerging evidence points to an important role of cytoskeleton associated proteins that assemble receptors and components of the subsynaptic machinery at postsynaptic membrane specializations. This article reviews interactions of inhibitory postsynaptic neurotransmitter receptors with the receptor anchoring protein gephyrin and intracellular components involved in downstream signalling and/or control of signal transduction processes. The presently available data suggest a central synaptic organizer function fur gephyrin in inhibitory postsynaptic membrane assembly and stabilization.

引用

页码：1 / 9

页数：9

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