Structural insights on the translation initiation complex: ghosts of a universal initiation complex

被引:36
作者
Allen, Gregory S.
Frank, Joachim
机构
[1] Hlth Res Inc, Howard Hughes Med Inst, Wadsworth Ctr, Albany, NY 12201 USA
[2] SUNY Albany, Dept Biomed Sci, Albany, NY 12201 USA
关键词
D O I
10.1111/j.1365-2958.2006.05574.x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
All living organisms utilize ribosomes to translate messenger RNA into proteins. Initiation of translation, the process of bringing together mRNA, initiator transfer RNA, and the ribosome, is therefore of critical importance to all living things. Two protein factors, IF1 (a/eIF1A) and IF2 (a/eIF5B), are conserved among all three kingdoms of life and have been called universal initiation factors (Roll-Mecak et al., 2001). Recent X-ray, NMR and cryo-EM structures of the universal factors, alone and in complex with eubacterial ribosomes, point to the structural homology among the initiation factors and initiation complexes. Taken together with genomic and functional evidence, the structural studies allow us to predict some features of eukaryotic and archaeal initiation complexes. Although initiation of translation in eukaryotes and archaea requires more initiation factors than in eubacteria we propose the existence of a common denominator initiation complex with structural and functional homology across all kingdoms of life.
引用
收藏
页码:941 / 950
页数:10
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