Sequence-specific DNA binding by noncovalent peptide-tripyrrole conjugates

被引：22

作者：

Blanco, Juan B.

Dodero, Veronica L.

Vazquez, M. Eugenio

Mosquera, Manuel

Castedo, Luis

Mascarenas, Jose L. ^{[1
]}

机构：

[1] Univ Santiago de Compostela, Fac Quim, Dept Quim Organ, E-15782 Santiago De Compostela, Spain

[2] Univ Santiago de Compostela, Fac Quim, Dept Quim Fis, E-15782 Santiago De Compostela, Spain

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 48期

关键词：

distamycin; DNA recognition; noncovalent interactions; peptides; proteins;

D O I：

10.1002/anie.200603115

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

To join the groove: Equipping basic-region bZIP peptides with a noncovalent heterodimerizing unit allows their major-groove DNA-binding capability to be triggered upon addition of appropriate external ligands that bind into adjacent minor-groove sites. The resulting noncovalent hybrids bind relatively long DNA sites with good affinity and very high specificity. (Figure Presented). © 2006 Wiley-VCH Verlag GmbH &. Co. KGaA.

引用

页码：8210 / 8214

页数：5

共 41 条

[1] Comparison of the sequence-selective DNA binding by peptide dimers with covalent and noncovalent dimerization domains [J].