Association between polymyositis and hepatitis C virus infection: treatment-related difficulties.

被引：11

作者：

Alric, L ^{[1
]}

Partensky, J ^{[1
]}

Reynaud, D ^{[1
]}

Rauzy, O ^{[1
]}

Duffaut, M ^{[1
]}

机构：

[1] CHU Purpan, Hop Purpan, Serv Med Interne, F-31059 Toulouse, France

来源：

REVUE DE MEDECINE INTERNE | 2000年 / 21卷 / 06期

关键词：

polymyositis; viral hepatitis C; HCV; interferon; intravenous gamma globulins;

D O I：

10.1016/S0248-8663(00)89230-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction. - Chronic hepatitis C virus infection is often associated with various auto-immune disorders. We report four cases of an association between polymyositis and hepatitis C virus infection. The course and the difficulties of therapy are discussed. Exegesis. - Among 510 consecutive patients infected by viral hepatitis C, we report four cases of polymyositis. Corticosteroids increased serum alanine aminotransferase levels in two cases, leading to severe liver injury in one patient. Worsening of polymyositis under interferon-a therapy was observed in one case. Clinical and biological stability were reported in another case. Aggravation of polymyositis with severe muscle weakness and dyspnea occurred in two patients after disruption of interferon-alpha. treatment. Intravenous gamma globulins subsequently improved their condition, without biological worsening of viral hepatitis. Conclusion. - These observations suggest an association between hepatitis C virus infection and polymyositis. Because corticosteroids can induce adverse effects in the liver, intravenous gamma globulins could be used for the treatment of this particular form of polymyositis. (C) 2000 Editions scientifiques ef medicales Elsevier SAS.

引用

页码：542 / 546

页数：5

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