Potent anti-inflammatory activity of 3-aminovinylphosphonates as inhibitors of reactive oxygen intermediates, nitric oxides generation, and tumor necrosis factor-alpha release

被引：24

作者：

Al Quntar, Abed Al Aziz

Gallily, Ruth

Katzavian, Galia

Srebnik, Morris ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Fac Med, Sch Pharm, Dept Med Chem & Nat Prod, IL-91120 Jerusalem, Israel

[2] Hebrew Univ Jerusalem, Hadassah Med Sch, Lautenberg Ctr Gen & Tumor Immunol, IL-91120 Jerusalem, Israel

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2007年 / 556卷 / 1-3期

关键词：

tumor necrosis factor-alpha; reactive oxygen intermediate; nitric oxide; aminovinylphosphonate; hydroxyvinylphosphonate; anti-inflammatory;

D O I：

10.1016/j.ejphar.2006.10.041

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Two 3-aminoalkenylphosphonate compounds 1, 2, and a hydroxyl derivative, 2-(3-hydroxy-3-phenylpropyl)hex-l-enylphosphonate 3, recently synthesized in our lab, have been evaluated for their ability to modulate the production of reactive oxygen intermediates, nitric oxide (NO) and tumor necrosis factor (TNF-alpha) by murine macrophages. We found that all three molecules suppressed generation of reactive oxygen intermediates, NO, and TNF-alpha. However, although 2-(3-hydroxy-3-phenylpropyl)hex-1-enylphosphonate 3 possessed higher activity in suppression of reactive oxygen intermediates and nitric oxide compared to 3-aminoalkenylphosphonates 1 and 2, it showed less activity in the inhibition of tumor necrosis factor release. (c) 2006 Elsevier B.V All rights reserved.

引用

页码：9 / 13

页数：5

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