EPIGENETICS AND GENETICS Leukaemogenesis: more than mutant genes

被引：250

作者：

Chen, Jianjun ^{[1
]}

Odenike, Olatoyosi ^{[1
]}

Rowley, Janet D. ^{[1
,2
]}

机构：

[1] Univ Chicago, Dept Med, Chicago, IL 60637 USA

[2] Univ Chicago, Med Ctr, Chicago, IL 60637 USA

来源：

NATURE REVIEWS CANCER | 2010年 / 10卷 / 01期

基金：

美国国家卫生研究院;

关键词：

ACUTE MYELOID-LEUKEMIA; ACUTE PROMYELOCYTIC LEUKEMIA; HISTONE DEACETYLASE INHIBITOR; TRANS-RETINOIC ACID; ACUTE MYELOGENOUS LEUKEMIA; POLYCOMB REPRESSIVE COMPLEX-2; MICRORNA EXPRESSION PROFILES; AGENT SODIUM PHENYLBUTYRATE; PML-RAR-ALPHA; VALPROIC ACID;

D O I：

10.1038/nrc2765

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Acute leukaemias are characterized by recurring chromosomal aberrations and gene mutations that are crucial to disease pathogenesis. It is now evident that epigenetic modifications, including DNA methylation and histone modifications, substantially contribute to the phenotype of leukaemia cells. An additional layer of epigenetic complexity is the pathogenetic role of microRNAs in leukaemias, and their key role in the transcriptional regulation of tumour suppressor genes and oncogenes. The genetic heterogeneity of acute leukaemias poses therapeutic challenges, but pharmacological agents that target components of the epigenetic machinery are promising as a component of the therapeutic arsenal for this group of diseases.

引用

收藏

页码：23 / 36

页数：14

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