Automated chemical synthesis: From resins to instruments

被引：15

作者：

Porco, JA

Deegan, T

Devonport, W

Gooding, OW

Heisler, K

Labadie, JW

Newcomb, B

Nguyen, C

vanEikeren, P

Wong, J

Wright, P

机构：

[1] Argonaut Technologies Inc., 887 G Industrial Road, San Carlos

来源：

MOLECULAR DIVERSITY | 1997年 / 2卷 / 04期

关键词：

solid-phase synthesis; polymer supports; linkers; automated organic synthesis; combinatorial chemistry; chemical synthesis development;

D O I：

10.1007/BF01715635

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Solid-phase organic synthesis is now a prevalent activity in drug discovery. In keeping with this keen interest is the need to develop reliable automated synthesis instrumentation as well as polymeric supports and linkers suitable for the full range of organic synthesis applications. In this paper, we review our activities in the development of new and enabling tools for automated chemical synthesis, including the following: (i) new solid supports such as ArgoGel(TM) (PS-PEG-based) and Argo-X203 (PS-based); and (ii) the Nautilus(TM) 2400 system, a fully closed and inert automated chemistry development workstation. Selected chemistry optimization and synthesis examples performed on the Nautilus and new solid supports will be described.

引用

页码：197 / 206

页数：10

共 18 条

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