Expression of Profi brotic Growth Factors and Their Receptors by Mouse Lung Macrophages and Fibroblasts under Conditions of Acute Viral Infl ammation in Infl uenza A/H5N1 Virus

被引：6

作者：

Anikina, A. G. ^{[1
,2
]}

Shkurupii, V. A. ^{[1
,2
]}

Potapova, O. V. ^{[1
]}

Kovner, A. V. ^{[1
]}

Shestopalov, A. M. ^{[1
]}

机构：

[1] Russian Acad Med Sci, Res Ctr Clin & Expt Med, Siberian Div, Novosibirsk, Russia

[2] Novosibirsk State Med Univ, Minist Hlth Russian Federat, Novosibirsk, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2014年 / 156卷 / 06期

关键词：

influenza A/H5N1 virus; lungs; fibrosis; profibrotic growth factors and their receptors; TNF-alpha;

D O I：

10.1007/s10517-014-2463-7

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Morphological signs of early interstitial fi brosis, developing under conditions of acute viral inflammation (postinfection days 1-14), were observed in C57Bl/6 mice infected with influenza A/H5N1 A/goose/Krasnoozerskoye/627/05 virus. The development of fi brosis was confirmed by an increase in the number of lung cells expressing TNF-alpha. These changes were recorded in the presence of a many-fold increase in the counts of macrophages and fi broblasts expressing FGF, EGF, and their receptors.

引用

页码：833 / 837

页数：5

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