Integration of the regulation of reproductive function and energy balance: lactation as a model

被引:133
作者
Smith, MS
Grove, KL
机构
[1] Oregon Hlth & Sci Univ, Div Neurosci, Beaverton, OR 97006 USA
[2] Oregon Hlth & Sci Univ, Oregon Natl Primate Res Ctr, Beaverton, OR 97006 USA
[3] Oregon Hlth & Sci Univ, Dept Physiol & Pharmacol, Beaverton, OR 97006 USA
关键词
D O I
10.1016/S0091-3022(02)00002-X
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Lactation is a physiological model for studying how the hypothalamus integrates peripheral signals, such as sensory signals (suckling stimulus) and those denoting energy balance (leptin), to alter hypothalamic function regulating food intake/energy balance and reproduction. The characteristics of food intake/energy balance during lactation are extreme hyperphagia, coupled with negative energy balance. The arcuate nucleus Neuropeptide Y (ARH-NPY) system is activated by: (1) brainstem projections specifically activated by the suckling stimulus, and (2) the decrease in leptin in response to the metabolic drain of milk production. NPY neurons from the ARH make direct contact with GnRH neurons and with CRH neurons in the PVH. NPY neurons also make contact with orexin and MCH neurons in the LHA, which, in turn, make contacts with GnRH neurons. Thus, the ARH-NPY system provides a neuroanatomical framework by which to integrate changes in food intake/energy with the regulation of cyclic reproductive function. (C) 2002 Elsevier Science (USA). All rights reserved.
引用
收藏
页码:225 / 256
页数:32
相关论文
共 198 条
[1]   LACTATION INHIBITS HIPPOCAMPAL AND CORTICAL ACTIVATION OF CFOS EXPRESSION BY NMDA BUT NOT KAINATE RECEPTOR AGONISTS [J].
ABBUD, R ;
LEE, WS ;
HOFFMAN, G ;
SMITH, MS .
MOLECULAR AND CELLULAR NEUROSCIENCE, 1992, 3 (03) :244-250
[2]   DIFFERENCES IN THE LUTEINIZING-HORMONE AND PROLACTIN RESPONSES TO MULTIPLE INJECTIONS OF KAINATE, AS COMPARED TO N-METHYL-D,L-ASPARTATE, IN CYCLING RATS [J].
ABBUD, R ;
SMITH, MS .
ENDOCRINOLOGY, 1991, 129 (06) :3254-3258
[3]   CORTICAL REFRACTORINESS TO N-METHYL-D,L-ASPARTIC ACID (NMA) STIMULATION IN THE LACTATING RAT - RECOVERY AFTER PUP REMOVAL AND BLOCKADE OF PROGESTERONE RECEPTORS [J].
ABBUD, R ;
HOFFMAN, GE ;
SMITH, MS .
BRAIN RESEARCH, 1993, 604 (1-2) :16-23
[4]  
ADLER RA, 1991, AM J PHYSL, V261
[5]   The responsiveness of tuberoinfundibular dopaminergic neurons to prolactin feedback is diminished between early lactation and midlactation in the rat [J].
Arbogast, LA ;
Voogt, JL .
ENDOCRINOLOGY, 1996, 137 (01) :47-54
[6]  
Aston-Jones Gary, 1995, P183
[7]   Melanin-concentrating hormone and neuropeptide EI projections from the lateral hypothalamic area and zona incerta to the medial septal nucleus and spinal cord: a study using multiple neuronal tracers [J].
Bittencourt, JC ;
Elias, CF .
BRAIN RESEARCH, 1998, 805 (1-2) :1-19
[8]   Y-receptor subtypes - How many more? [J].
Blomqvist, AG ;
Herzog, H .
TRENDS IN NEUROSCIENCES, 1997, 20 (07) :294-298
[9]   PROLACTIN BRAIN INTERACTIONS IN THE INDUCTION OF MATERNAL-BEHAVIOR IN RATS [J].
BRIDGES, RS ;
MANN, PE .
PSYCHONEUROENDOCRINOLOGY, 1994, 19 (5-7) :611-622
[10]   THE ROLE OF LACTOGENIC HORMONES IN MATERNAL-BEHAVIOR IN FEMALE RATS [J].
BRIDGES, RS .
ACTA PAEDIATRICA, 1994, 83 :33-39