Qualimap 2: advanced multi-sample quality control for high-throughput sequencing data

被引：1395

作者：

Okonechnikov, Konstantin ^{[1
]}

Conesa, Ana ^{[2
,3
]}

Garcia-Alcalde, Fernando ^{[1
]}

机构：

[1] Max Planck Inst Infect Biol, Dept Mol Biol, D-10117 Berlin, Germany

[2] Ctr Invest Principe Felipe, Genom Gene Express Lab, Valencia 46012, Spain

[3] Univ Florida, Inst Food & Agr Res, Microbiol & Cell Sci Dept, Gainesville, FL 32611 USA

来源：

BIOINFORMATICS | 2016年 / 32卷 / 02期

关键词：

D O I：

10.1093/bioinformatics/btv566

中图分类号：

Q5 [生物化学];

学科分类号：

070307 [化学生物学];

摘要：

Motivation: Detection of random errors and systematic biases is a crucial step of a robust pipeline for processing high-throughput sequencing (HTS) data. Bioinformatics software tools capable of performing this task are available, either for general analysis of HTS data or targeted to a specific sequencing technology. However, most of the existing QC instruments only allow processing of one sample at a time. Results: Qualimap 2 represents a next step in the QC analysis of HTS data. Along with comprehensive single-sample analysis of alignment data, it includes new modes that allow simultaneous processing and comparison of multiple samples. As with the first version, the new features are available via both graphical and command line interface. Additionally, it includes a large number of improvements proposed by the user community.

引用

页码：292 / 294

页数：3

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