The role of CCK2 receptors in energy homeostasis:: insights from the CCK2 receptor-deficient mouse

被引:32
作者
Weiland, TJ [1 ]
Voudouris, NJ [1 ]
Kent, S [1 ]
机构
[1] La Trobe Univ, Sch Psychol Sci, Bundoora, Vic 3086, Australia
关键词
cholecystokinin; CCK; CCK2; receptors; energy homeostasis; body temperature; food intake; locomotor activity;
D O I
10.1016/j.physbeh.2004.04.065
中图分类号
B84 [心理学];
学科分类号
04 ; 0402 ;
摘要
The present study explored the contribution of type 2 cholecystokinin (CCK) receptors in energy regulation. A total of 78 CCK2 receptor-deficient mice and 80 wild-type controls were acclimated to a 12:12 light-dark cycle at 30 +/- 1 degreesC. Using a computer-monitored biotelemetry system, circadian patterns of body temperature, food intake, and activity were monitored for 4 days. Body weight and water consumption were manually recorded during this period. Results indicate that CCK2 receptor invalidation produces elevated body temperature during both the photophase and scotophase (by 0.3 8 and 0.12 degreesC, respectively), increased body weight (29.3 +/- 0.2 vs. 26.8 +/- 0.2 g) and water consumption (4.1 +/- 0.1 vs. 3.2 +/- 0.1 ml), and decreased scotophase locomotor activity (WT: 7.0 +/- 0.2 vs. KO: 6.1 +/- 0.2 counts/min). These findings suggest an important role for CCK2 receptors in processes underlying energy regulation during basal and possibly pathological states. (C) 2004 Elsevier Inc. All rights reserved.
引用
收藏
页码:471 / 476
页数:6
相关论文
共 41 条
[1]   EFFECTS OF SELECTIVE CCK RECEPTOR AGONISTS ON FOOD-INTAKE AFTER CENTRAL OR PERIPHERAL ADMINISTRATION IN RATS [J].
ASIN, KE ;
GORE, PA ;
BEDNARZ, L ;
HOLLADAY, M ;
NADZAN, AM .
BRAIN RESEARCH, 1992, 571 (01) :169-174
[2]   CHOLECYSTOKININ-A-RECEPTOR MEDIATION OF FOOD-INTAKE IN CATS [J].
BADO, A ;
DURIEUX, C ;
MOIZO, L ;
ROQUES, BP ;
LEWIN, MJM .
AMERICAN JOURNAL OF PHYSIOLOGY, 1991, 260 (04) :R693-R697
[3]  
CRAWLEY JN, 1991, J PHARMACOL EXP THER, V257, P1076
[4]   CHOLECYSTOKININ REDUCES EXPLORATORY-BEHAVIOR IN MICE [J].
CRAWLEY, JN ;
HAYS, SE ;
PAUL, SM ;
GOODWIN, FK .
PHYSIOLOGY & BEHAVIOR, 1981, 27 (03) :407-411
[5]   Examining the effects of lipopolysaccharide and cholecystokinin on water ingestion: comparing intake and palatability [J].
Cross-Mellor, SK ;
Kent, WDT ;
Kavaliers, M ;
Ossenkopp, KP .
BRAIN RESEARCH, 2000, 861 (02) :220-232
[6]   Peripheral stimulation of CCK-B receptors by BC264 induces a hyperexploration, dependent on the partial derivative opioid system in the nucleus accumbens of rat [J].
Daugé, V ;
Samir, A ;
Cupo, A ;
Roques, BP .
NEUROPHARMACOLOGY, 1999, 38 (07) :999-1007
[7]   Mutant mice lacking the cholecystokinin2 receptor show a dopamine-dependent hyperactivity and a behavioral sensitization to morphine [J].
Daugé, V ;
Beslot, F ;
Matsui, T ;
Roques, BP .
NEUROSCIENCE LETTERS, 2001, 306 (1-2) :41-44
[8]   Behavioral profile of CCK2 receptor-deficient mice [J].
Daugé, V ;
Sebret, A ;
Beslot, F ;
Matsui, T ;
Roques, BP .
NEUROPSYCHOPHARMACOLOGY, 2001, 25 (05) :690-698
[9]   Interaction of serotonin and cholecystokinin in the lateral parabrachial nucleus to control sodium intake [J].
De Gobbi, JIF ;
De Luca, LA ;
Johnson, AK ;
Menani, JV .
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2001, 280 (05) :R1301-R1307
[10]   CholecystokininB receptor antagonist increases food intake in rats [J].
Dorré, D ;
Smith, GP .
PHYSIOLOGY & BEHAVIOR, 1998, 65 (01) :11-14