Understanding the unique mechanism of L-FMAU (clevudine) against hepatitis B virus: Molecular dynamics studies

被引：42

作者：

Chong, YH ^{[1
]}

Chu, CK ^{[1
]}

机构：

[1] Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 23期

关键词：

D O I：

10.1016/S0960-894X(02)00747-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The molecular dynamics simulation of HBV-polymerase(.)DNA(.)L-FMAU-TP complex demonstrated that L-FMAU-TP may not serve as a substrate for HBV polymerase because the appropriate binding of L-FMAU-TP to the active site of HBV polymerase may not take place without the unfavorable conformational adjustment, which prevents L-FMAU-TP from being incorporated into the groaning viral DNA chain. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：3459 / 3462

页数：4

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