17 beta-estradiol protects against NMDA-induced excitotoxicity by direct inhibition of NMDA receptors

被引：248

作者：

Weaver, CE ^{[1
]}

ParkChung, M ^{[1
]}

Gibbs, TT ^{[1
]}

Farb, DH ^{[1
]}

机构：

[1] BOSTON UNIV,SCH MED,DEPT PHARMACOL & EXPT THERAPEUT,MOL NEUROBIOL LAB,BOSTON,MA 02118

来源：

BRAIN RESEARCH | 1997年 / 761卷 / 02期

关键词：

NMDA; glutamate receptor; steroid; estradiol; excitotoxicity; calcium; neuroprotection;

D O I：

10.1016/S0006-8993(97)00449-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Several lines of evidence suggest that 17 beta-estradiol (beta E-2) has neuroprotective properties. The risk and severity of dementia are decreased in women who have received estrogen therapy, and beta E-2 protects neurons in vitro against death from a variety of stressors. Neuroprotection by beta E-2 has been suggested to be due to free radical scavenging. We demonstrate an additional neuroprotective mechanism whereby beta E2 protects against NMDA-induced neuronal death by directly inhibiting the NMDA receptor. (C) 1997 Elsevier Science B.V.

引用

页码：338 / 341

页数：4

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