Target cell-specific modulation of neuronal activity by astrocytes

被引：183

作者：

Kozlov, A. S. ^{[1
]}

Angulo, M. C. ^{[1
]}

Audinat, E. ^{[1
]}

Charpak, S. ^{[1
]}

机构：

[1] Rockefeller Univ, Lab Sensory Neurosci, New York, NY 10021 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2006年 / 103卷 / 26期

关键词：

glutamate; GABA; inhibition; olfactory bulb; synchronization;

D O I：

10.1073/pnas.0603741103

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Interaction between astrocytes and neurons enriches the behavior of brain circuits. By releasing glutamate and ATP, astrocytes can directly excite neurons and modulate synaptic transmission. In the rat olfactory bulb, we demonstrate that the release of GABA by astrocytes causes long-lasting and synchronous inhibition of mitral and granule cells. In addition, astrocytes release glutamate, leading to a selective activation of granule-cell NMDA receptors. Thus, by releasing excitatory and inhibitory neurotransmitters, astrocytes exert a complex modulatory control on the olfactory network.

引用

页码：10058 / 10063

页数：6

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