Are desmoglein autoantibodies essential for the immunopathogenesis of pemphigus vulgaris, or just 'witnesses of disease'?

被引：85

作者：

Amagai, M.

Ahmed, A. R.

Kitajima, Y.

Bystryn, J. C.

Milner, Y.

Gniadecki, R.

Hertl, M.

Pincelli, C.

Fridkis-Hareli, M.

Aoyama, Y.

Frusic-Zlotkin, M.

Mueller, E.

David, M.

Mimouni, D.

Vind-Kezunovic, D.

Michel, B.

Mahoney, M.

Grando, S.

机构：

[1] Keio Univ, Sch Med, Dept Dermatol, Shinjuku Ku, Tokyo 1608582, Japan

[2] Univ Copenhagen, Bispebjerg Hosp, Dept Dermatol, DK-2400 Copenhagen NV, Denmark

[3] Univ Modena & Reggio Emilia, Inst Dermatol, I-41100 Modena, Italy

[4] Univ Marburg, Dept Dermatol & Allergol, D-35033 Marburg, Germany

[5] New England Baptist Hosp, Dept Med, Ctr Blistering Dis, Boston, MA 02120 USA

[6] Harvard Univ, Sch Dent Med, Dept Oral Med Infect & Immun, Boston, MA 02115 USA

[7] Gifu Univ, Sch Med, Dept Dermatol, Gifu 5011194, Japan

[8] NYU, Sch Med, Ronald O Perleman Dept Dermatol, New York, NY 10026 USA

[9] Hebrew Univ Jerusalem, Dept Life Sci, Myers Skin Biol & Biochem Lab, IL-91904 Jerusalem, Israel

[10] Rabin Med Ctr, Dept Dermatol, Petah Tiqwa, Israel

[11] Beno Michel MD Inc, Beachwood, OH USA

[12] Univ Calif Davis, Dept Dermatol, Sacramento, CA 95816 USA

[13] Thomas Jefferson Univ, Jefferson Med Coll, Dept Dermatol & Cutaneous Biol, Philadelphia, PA 19107 USA

[14] Univ Bern, Inst Anim Pathol, Bern, Switzerland

来源：

EXPERIMENTAL DERMATOLOGY | 2006年 / 15卷 / 10期

关键词：

acantholysis; adhesion; apoptosis; autoantibody; cytoskeleton; desmoglein; desmosomes; pathogenesis; pemphigus;

D O I：

10.1111/j.1600-0625.2006.00499.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

引用

页码：815 / 831

页数：25

共 202 条

[1] Mice expressing a mutant desmosomal cadherin exhibit abnormalities in desmosomes, proliferation, and epidermal differentiation [J].

Allen, E ;

Yu, QC ;

Fuchs, E .

JOURNAL OF CELL BIOLOGY, 1996, 133 (06) :1367-1382

[2] EXTRACELLULAR DOMAIN OF PEMPHIGUS-VULGARIS ANTIGEN (DESMOGLEIN-3) MEDIATES WEAK HEMOPHILIC ADHESION (VOL 102, PG 402, 1994) [J].

AMAGAI .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1994, 103 (04) :608-615

[3] Toxin in bullous impetigo and staphylococcal scalded-skin syndrome targets desmoglein 1 [J].

Amagai, M ;

Matsuyoshi, N ;

Wang, ZH ;

Andl, C ;

Stanley, JR .

NATURE MEDICINE, 2000, 6 (11) :1275-1277

[4] AUTOANTIBODIES AGAINST A NOVEL EPITHELIAL CADHERIN IN PEMPHIGUS-VULGARIS, A DISEASE OF CELL-ADHESION [J].

AMAGAI, M ;

KLAUSKOVTUN, V ;

STANLEY, JR .

CELL, 1991, 67 (05) :869-877

[5] ANTIGEN-SPECIFIC IMMUNOADSORPTION OF PATHOGENIC AUTOANTIBODIES IN PEMPHIGUS FOLIACEUS [J].

AMAGAI, M ;

HASHIMOTO, T ;

GREEN, KJ ;

SHIMIZU, N ;

NISHIKAWA, T .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1995, 104 (06) :895-901

[6] Use of autoantigen-knockout mice in developing an active disease model for pemphigus [J].

Amagai, M ;

Tsunoda, K ;

Suzuki, H ;

Nishifuji, K ;

Koyasu, S ;

Nishikawa, T .

JOURNAL OF CLINICAL INVESTIGATION, 2000, 105 (05) :625-631

[7] Desmoglein as a target in autoimmunity and infection [J].

Amagai, M .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2003, 48 (02) :244-252

[8] The clinical phenotype of pemphigus is defined by the anti-desmoglein autoantibody profile [J].

Amagai, M ;

Tsunoda, K ;

Zillikens, D ;

Nagai, T ;

Nishikawa, T .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1999, 40 (02) :167-170

[9] AUTOANTIBODIES AGAINST THE AMINO-TERMINAL CADHERIN-LIKE BINDING DOMAIN OF PEMPHIGUS-VULGARIS ANTIGEN ARE PATHOGENIC [J].

AMAGAI, M ;

KARPATI, S ;

PRUSSICK, R ;

KLAUSKOVTUN, V ;

STANLEY, JR .

JOURNAL OF CLINICAL INVESTIGATION, 1992, 90 (03) :919-926

[10] ABSORPTION OF PATHOGENIC AUTOANTIBODIES BY THE EXTRACELLULAR DOMAIN OF PEMPHIGUS-VULGARIS ANTIGEN (DSG3) PRODUCED BY BACULOVIRUS [J].

AMAGAI, M ;

HASHIMOTO, T ;

SHIMIZU, N ;

NISHIKAWA, T .

JOURNAL OF CLINICAL INVESTIGATION, 1994, 94 (01) :59-67

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