Thyroid hormone regulates NGF content and p75(LNGFR) expression in the basal forebrain of adult rats

被引：34

作者：

Calza, L

Giardino, L

Aloe, L

机构：

[1] HESPERIA HOSP, PATHOPHYSIOL CTR NERVOUS SYST, MODENA, ITALY

[2] UNIV MILAN, IST OTOLARYNGOL 2, MILAN, ITALY

[3] CNR, INST NEUROBIOL, ROME, ITALY

来源：

EXPERIMENTAL NEUROLOGY | 1997年 / 143卷 / 02期

关键词：

D O I：

10.1006/exnr.1996.6361

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Several lines of data from human and animal studies have suggested a role of thyroid hormone in the regulation of cholinergic neurons in the adult brain. In this study we have investigated the content of nerve growth factor (NGF) and the expression of NGF low affinity receptor (p75(LNGFR)) in the basal forebrain of adult hypothyroid rats. We describe an increase of both NC;F and p75(LNGFR) expression in the basal forebrain of adult hypothyroid rats. The administration of colchicine up-regulates p75(LNGFR) expression in both hypo- and control rats, whereas it fails to down-regulate choline acetyl transferase mRNA expression during hypothyroidism. These data offer a possible neurobiological explanation to cognitive defects observed during adult hypothyroidism in humans. (C) 1997 Academic Press.

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页码：196 / 206

页数：11

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