Toll receptors, CD14, and macrophage activation and deactivation by LPS

被引:445
作者
Dobrovolskaia, MA [1 ]
Vogel, SN [1 ]
机构
[1] Uniformed Serv Univ Hlth Sci, Dept Microbiol & Immunol, Bethesda, MD 20814 USA
关键词
Toll-like receptors (TLR); CD14; lipopolysaccharide (LPS); signal transduction; macrophage; endotoxin tolerance; septic shock; inflammation; cytokines;
D O I
10.1016/S1286-4579(02)01613-1
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
This review will focus on the molecular mechanisms of macrophage activation and desensitization by bacterial lipopolysaccharide (LPS). The most recent advances in the understanding of the function of the LPS receptor complex and its role in the development of the septic shock syndrome and endotoxin tolerance will be discussed. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
引用
收藏
页码:903 / 914
页数:12
相关论文
共 100 条
  • [1] ABRAHAM E, 1989, J IMMUNOL, V142, P899
  • [2] Adib-Conquy M, 2001, J LEUKOCYTE BIOL, V70, P30
  • [3] Cutting edge: Cell surface expression and lipopolysaccharide signaling via the Toll-like receptor 4-MD-2 complex on mouse peritoneal macrophages
    Akashi, S
    Shimazu, R
    Ogata, H
    Nagai, Y
    Takeda, K
    Kimoto, M
    Miyake, K
    [J]. JOURNAL OF IMMUNOLOGY, 2000, 164 (07) : 3471 - 3475
  • [4] Toll-like receptors: critical proteins linking innate and acquired immunity
    Akira, S
    Takeda, K
    Kaisho, T
    [J]. NATURE IMMUNOLOGY, 2001, 2 (08) : 675 - 680
  • [5] TLR4 mutations are associated with endotoxin hyporesponsiveness in humans
    Arbour, NC
    Lorenz, E
    Schutte, BC
    Zabner, J
    Kline, JN
    Jones, M
    Frees, K
    Watt, JL
    Schwartz, DA
    [J]. NATURE GENETICS, 2000, 25 (02) : 187 - +
  • [6] Bhat N, 1999, J IMMUNOL, V162, P7335
  • [7] Regulation of an essential innate immune response by the p50 subunit of NF-κB
    Bohuslav, J
    Kravchenko, VV
    Parry, GCN
    Erlich, JH
    Gerondakis, S
    Mackman, N
    Ulevitch, RJ
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1998, 102 (09) : 1645 - 1652
  • [8] Brade H., 1999, ENDOTOXIN HLTH DIS
  • [9] Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction
    Chow, JC
    Young, DW
    Golenbock, DT
    Christ, WJ
    Gusovsky, F
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (16) : 10689 - 10692
  • [10] CONNALL TP, 1994, ARCH SURG-CHICAGO, V129, P1153