学术探索
学术期刊
新闻热点
数据分析
智能评审

Protein kinases as mediators of phosphoinositide 3-kinase signaling

被引：262
作者：
Toker, A [1 ]
机构：
[1] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Pathol, Boston, MA 02215 USA
来源：
MOLECULAR PHARMACOLOGY | 2000年 / 57卷 / 04期
关键词：
D O I：
10.1124/mol.57.4.652
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
引用
收藏
页码：652 / 658
页数：7
相关论文
共 58 条
  • [1] Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase B alpha
    Alessi, DR
    James, SR
    Downes, CP
    Holmes, AB
    Gaffney, PRJ
    Reese, CB
    Cohen, P
    [J]. CURRENT BIOLOGY, 1997, 7 (04) : 261 - 269
  • [2] 3 Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro
    Alessi, DR
    Kozlowski, MT
    Weng, QP
    Morrice, N
    Avruch, J
    [J]. CURRENT BIOLOGY, 1998, 8 (02) : 69 - 81
  • [3] Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B
    Anderson, KE
    Coadwell, J
    Stephens, LR
    Hawkins, PT
    [J]. CURRENT BIOLOGY, 1998, 8 (12) : 684 - 691
  • [4] Role of translocation in the activation and function of protein kinase B
    Andjelkovic, M
    Alessi, DR
    Meier, R
    Fernandez, A
    Lamb, NJC
    Frech, M
    Cron, P
    Cohen, P
    Lucocq, JM
    Hemmings, BA
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (50) : 31515 - 31524
  • [5] Evidence that 3-phosphoinositide-dependent protein kinase-1 mediates phosphorylation of p70 56 kinase in vivo at Thr-412 as well as Thr-252
    Balendran, A
    Currie, R
    Armstrong, CG
    Avruch, J
    Alessi, DR
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (52) : 37400 - 37406
  • [6] PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2
    Balendran, A
    Casamayor, A
    Deak, M
    Paterson, A
    Gaffney, P
    Currie, R
    Downes, CP
    Alessi, DR
    [J]. CURRENT BIOLOGY, 1999, 9 (08) : 393 - 404
  • [7] The hydrophobic phosphorylation motif of conventional protein kinase C is regulated by autophosphorylation
    Behn-Krappa, A
    Newton, AC
    [J]. CURRENT BIOLOGY, 1999, 9 (14) : 728 - 737
  • [8] Bifurcation of lipid and protein kinase signals of PI3Kγ to the protein kinases PKB and MAPK
    Bondeva, T
    Pirola, L
    Bulgarelli-Leva, G
    Rubio, I
    Wetzker, R
    Wymann, MP
    [J]. SCIENCE, 1998, 282 (5387) : 293 - 296
  • [9] Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor
    Brunet, A
    Bonni, A
    Zigmond, MJ
    Lin, MZ
    Juo, P
    Hu, LS
    Anderson, MJ
    Arden, KC
    Blenis, J
    Greenberg, ME
    [J]. CELL, 1999, 96 (06) : 857 - 868
  • [10] Role of diacylglycerol-regulated protein kinase C isotypes in growth factor activation of the Raf-1 protein kinase
    Cai, H
    Smola, U
    Wixler, V
    EisenmannTappe, I
    DiazMeco, MT
    Moscat, J
    Rapp, U
    Cooper, GM
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 1997, 17 (02) : 732 - 741
123456