Myeloid C-type lectins in innate immunity

被引:401
作者
Robinson, Matthew J. [1 ]
Sancho, David [1 ]
Slack, Emma C. [1 ]
LeibundGut-Landmann, Salome [1 ]
Sousa, Caetano Reis e [1 ]
机构
[1] London Res Inst, Canc Res UK, Immunobiol Lab, London WC2A 3PX, England
基金
瑞士国家科学基金会;
关键词
D O I
10.1038/ni1417
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
C-type lectins expressed on myeloid cells comprise a family of proteins that share a common structural motif, and some act as receptors in pathogen recognition. But just as the presence of leucine-rich repeats alone is not sufficient to define a Toll-like receptor, the characterization of C-type lectin receptors in innate immunity requires the identification of accompanying signaling motifs. Here we focus on the known signaling pathways of myeloid C-type lectins and on their possible functions as autonomous activating or inhibitory receptors involved in innate responses to pathogens or self.
引用
收藏
页码:1258 / 1265
页数:8
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