Role of potassium channels in the central neurogenic neuroprotection elicited by cerebellar stimulation in rat

被引：25

作者：

Golanov, EV ^{[1
]}

Christensen, JD ^{[1
]}

Reis, DJ ^{[1
]}

机构：

[1] Cornell Univ, Weill Med Coll, Dept Neurol & Neurosci, New York, NY 10021 USA

来源：

BRAIN RESEARCH | 1999年 / 842卷 / 02期

关键词：

focal ischemia; ATP-dependent potassium channel; cerebellar fastigial nucleus; pre-conditioning; stimulation; glibenclamide;

D O I：

10.1016/S0006-8993(99)01871-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Electrical stimulation of the cerebellar fastigial nucleus (FN) in spontaneously hypertensive (SHR), Wistar-Kyoto (WKY) and Fisher rats reduced, by similar to 50%, the infarctions produced by occlusion of the middle cerebral artery. Blockade of ATP-dependent potassium (K-ATP) channels with glibenclimide (i.c.v.) abolished salvage only in the SHR rat. While blockade of K-ATP channels failed to abolish salvage in WKY and Fisher rats, participation of potassium channels in neurogenic neuroprotection cannot be excluded. (C) 1999 Published by Elsevier Science B.V. All rights reserved.

引用

页码：496 / 500

页数：5

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