E and ID proteins branch out

被引：251

作者：

Kee, Barbara L. ^{[1
]}

机构：

[1] Univ Chicago, Dept Pathol, Comm Immunol Canc Biol & Dev Biol, Chicago, IL 60637 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2009年 / 9卷 / 03期

基金：

美国国家卫生研究院;

关键词：

LOOP-HELIX PROTEINS; B-CELL FACTOR; HEMATOPOIETIC STEM-CELLS; NATURAL-KILLER-CELL; ACUTE LYMPHOBLASTIC-LEUKEMIA; TRANSCRIPTION FACTOR E2-2; DELTA T-CELLS; FACTOR SPI-B; LYMPHOCYTE DEVELOPMENT; GENE-EXPRESSION;

D O I：

10.1038/nri2507

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

E and inhibitor of DNA binding (ID) proteins are transcriptional regulators that function in many developmental processes in vertebrates and invertebrates. One subset of E proteins, the E2A proteins, have a central role in the transcriptional regulatory networks that promote commitment to and differentiation of the B- and T-cell lineages, and their function in these lineages is modulated by ID proteins. In this Review, I discuss recent studies that reveal a more extensive role for E and ID proteins in the transcriptional networks that drive the differentiation of many lymphoid lineages, as well as new functions for these proteins in haematopoietic stem cells and their multipotent, but lymphoid-primed, progeny.

引用

页码：175 / 184

页数：10

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