Spontaneous mutators in bacteria: Insights into pathways of mutagenesis and repair

被引：199

作者：

Miller, JH

机构：

[1] Dept. Microbiol. and Molec. Genet., Life Sciences Building, Univ. of California at Los Angeles, Los Angeles, CA 90049

来源：

ANNUAL REVIEW OF MICROBIOLOGY | 1996年 / 50卷

关键词：

microorganisms; repair systems; mutation; cancer; carcinogenesis;

D O I：

10.1146/annurev.micro.50.1.625

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Mutators are cells that have a higher mutation rate than the wild type. Such mutators have been extensively studied in bacteria, and this has led to the elucidation of a number of important DNA repair pathways, as well as revealing new pathways of mutagenesis. Repair defects in humans that lead to mutator phenotypes are responsible for a number of cancer susceptibilities. In some cases, these repair systems are the close counterparts of the equivalent bacterial repair system. Therefore, characterizing bacterial mutators and the repair systems that are deficient can aid in discovering the human homolog of these systems.

引用

页码：625 / 643

页数：19

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