Early life factors contribute to the decrease in lung function between ages 18 and 40 - The coronary artery risk development in young adults study

被引:119
作者
Apostol, GG
Jacobs, DR
Tsai, AW
Crow, RS
Williams, OD
Townsend, MC
Beckett, WS
机构
[1] Univ Minnesota, Sch Publ Hlth, Div Epidemiol, Minneapolis, MN 55454 USA
[2] Univ Oslo, Inst Nutr Res, Oslo, Norway
[3] Ingenix Pharmaceut Serv, Eden Prairie, MN USA
[4] Univ Alabama Birmingham, Div Prevent Med, Birmingham, AL USA
[5] MC Townsend Associates, Pittsburgh, PA USA
[6] Univ Rochester, Dept Environm Med, Occupat Med Div, Rochester, NY USA
关键词
lung development; family smoking; smoking; asthma;
D O I
10.1164/rccm.2007035
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Early life factors may influence pulmonary function. We measured forced expiratory volume in 1 second (FEV1) in 1985-1986 and 2, 5, and 10 years later in approximately 4,000 black and white men and women initially aged 18-30 years. We estimated the age pattern of FEV1 according to family smoking status, early diagnosis of asthma, early smoking initiation, adult asthma, and cigarette smoking. FEV1 followed a quadratic pattern from age of peak through age 40. The pattern varied by race and sex. Early smoking initiation was associated with a faster decrease in FEV1. Smoking by family members was related to early life asthma and may have contributed to faster FEV1 decrease by encouraging behaviors such as heavier smoking or earlier smoking initiation. Prevalence of smoking was 28% when no family member smoked, compared with 59% when four or more members smoked. The FEV1 decline was 8.5% in never-smokers without asthma; 10.1% in nonsmoking individuals diagnosed with asthma; and 11.1% in baseline smokers who smoked 15 or more cigarettes per day. The combination of asthma and heavier smoking was synergistic (17.8% decline). This study delineates an increased rate of decline in those with asthma or in those who smoke cigarettes and implicates early life exposures as contributing to the faster rate of FEV1 decline.
引用
收藏
页码:166 / 172
页数:7
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