A new triterpene and anti-hepatitis B virus active compounds from Alisma orientalis

被引：117

作者：

Jiang, Zhi-Yong

Zhang, Xue-Mei

Zhang, Feng-Xue

Liu, Ni

Zhao, Fang

Zhou, Jun

Chen, Ji-Jun ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China

[2] Guangzhou Univ Chinese Tradit Med, Inst Trop Med Sci, Guangzhou, Peoples R China

[3] Chinese Acad Sci, Joint Lab Anti Viral Nat Med, Kunming Branch, Kunming 650204, Yunnan, Peoples R China

来源：

PLANTA MEDICA | 2006年 / 72卷 / 10期

关键词：

PROTOSTANE-TYPE TRITERPENES; ABSOLUTE STEREOSTRUCTURES; AQUATIC PLANTS; CRUDE DRUGS; RHIZOMA; SESQUITERPENES; CONSTITUENTS; 23-ACETATE; ALISMOXIDE;

D O I：

10.1055/s-2006-947178

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new triterpencid named alisol 0 (1) was isolated from the rhizomes of Alisma orientalis, together with six known compounds: alisol A 24-acetate (2), 25-anhydroalisol A (3),13 beta,17 beta-epoxyalisol A (4), alisol B 23-acetate (5), alisol F (6), and alisol F 24-acetate (7). Based on 1D and 2D-NMR data (HMQC, HMBC, COSY, ROESY), the structure of the new compound was deduced to be 11-dehydroxy-12-dehydroalisol F-24-acetate (1). Compounds 2-7 exhibited inhibitory activity in vitro on hepatitis B virus (HBV) surface antigen (HBsAg) secretion of the Hep G2.2.15 cell line with IC50 values of 2.3,11.0,15.4,14.3, 0.6 and 7.7 mu M, and on HBV e antigen (HBeAg) secretion with IC50 values of 498.1, 17.6, 41.0,19.9, 8.5 and 5.1 mu M, respectively.

引用

页码：951 / 954

页数：4

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