H3K9me3-Dependent Heterochromatin: Barrier to Cell Fate Changes

被引：333

作者：

Becker, Justin S. ^{[1
,2
]}

Nicetto, Dario ^{[1
,2
]}

Zaret, Kenneth S. ^{[1
,2
]}

机构：

[1] Univ Penn, Smilow Ctr Translat Res, Perelman Sch Med, Inst Regenerat Med,Epigenet Program, Philadelphia, PA 19104 USA

[2] Univ Penn, Smilow Ctr Translat Res, Perelman Sch Med, Dept Cell & Dev Biol, Philadelphia, PA 19104 USA

来源：

TRENDS IN GENETICS | 2016年 / 32卷 / 01期

关键词：

EMBRYONIC STEM-CELLS; HISTONE-H3; LYSINE-9; METHYLATION; MOUSE SOMATIC-CELLS; CONSTITUTIVE HETEROCHROMATIN; DEVELOPMENTAL REGULATORS; CHROMATIN-STRUCTURE; DNA METHYLATION; FACULTATIVE HETEROCHROMATIN; REPROGRAMMING FACTORS; H3K9;

D O I：

10.1016/j.tig.2015.11.001

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Establishing and maintaining cell identity depends on the proper regulation of gene expression, as specified by transcription factors and reinforced by epigenetic mechanisms. Among the epigenetic mechanisms, heterochromatin formation is crucial for the preservation of genome stability and the cell type-specific silencing of genes. The heterochromatin-associated histone mark H3K9me3, although traditionally associated with the noncoding portions of the genome, has emerged as a key player in repressing lineage-inappropriate genes and shielding them from activation by transcription factors. Here we describe the role of H3K9me3 heterochromatin in impeding the reprogramming of cell identity and the mechanisms by which H3K9me3 is reorganized during development and cell fate determination.

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页码：29 / 41

页数：13

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