Transglutaminase 2: an enigmatic enzyme with diverse functions

被引：491

作者：

Fesus, L ^{[1
]}

Piacentini, M

机构：

[1] Univ Debrecen, Fac Med, Med & Hlth Sci Ctr, Dept Biochem & Mol Biol, H-4012 Debrecen, Hungary

[2] Univ Roma Tor Vergata, Dept Biol, I-00173 Rome, Italy

[3] INMIIRCCS Lazzaro Spallanzani, Rome, Italy

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2002年 / 27卷 / 10期

基金：

匈牙利科学研究基金会;

关键词：

D O I：

10.1016/S0968-0004(02)02182-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transglutaminase 2 (TG2) is an inducible transamidating acyltransferase that catalyzes Ca2+-dependent protein modifications. It acts as a G protein in transmembrane signalling and as a cell surface adhesion mediator, this distinguishes it from other members of the transglutaminase family. The sequence motifs and domains revealed in the recent TG2 structure, can each be assigned distinct cellular functions, including the regulation of cytoskeleton, cell adhesion and cell death. Ablation of TG2 in mice results in impaired wound healing, autoimmunity and diabetes, reflecting the number and variety of TG2 functions. An important role for the enzyme in the pathogenesis of coeliac disease, fibrosis and neurodegenerative disorders has also been demonstrated, making TG2 an important therapeutic target.

引用

页码：534 / 539

页数：6

共 65 条

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