How receptors talk to trimeric G proteins

被引：489

作者：

Bourne, HR ^{[1
]}

机构：

[1] UNIV CALIF SAN FRANCISCO,INST CARDIOVASC RES,SAN FRANCISCO,CA 94143

来源：

CURRENT OPINION IN CELL BIOLOGY | 1997年 / 9卷 / 02期

关键词：

D O I：

10.1016/S0955-0674(97)80054-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Stimulated by hormones and sensory stimuli, serpentine receptors promote the release of GDP that is bound to the a subunit of trimeric G proteins and its replacement by GTP. Recent investigations have begun to define the sizes, shapes, and relative orientations of receptors and G proteins, ?he surfaces through which they interact with one another, and conformational changes in both sets of molecules that underlie receptor-catalyzed guanine-nucleotide exchange.

引用

页码：134 / 142

页数：9

共 66 条

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