Microarray analysis in sperm from fertile and infertile men without basic sperm analysis abnormalities reveals a significantly different transcriptome

被引：83

作者：

Garrido, N. ^{[1
,2
]}

Martinez-Conejero, J. A. ^{[2
]}

Jauregui, J. ^{[1
]}

Horcajadas, J. A. ^{[2
]}

Simon, C. ^{[1
,2
]}

Remohi, J. ^{[1
,2
]}

Meseguer, M. ^{[1
,2
]}

机构：

[1] Univ Valencia, Inst Valenciano Infertil, Valencia, Spain

[2] Univ Valencia, Fdn IVI, Dept Obstet & Gynecol, Valencia, Spain

来源：

FERTILITY AND STERILITY | 2009年 / 91卷 / 04期

关键词：

SPERMATOZOAL RNA; MESSENGER-RNA; EXPRESSION; GENOME;

D O I：

10.1016/j.fertnstert.2008.01.078

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Sperm analysis following World Health Organization guidelines is unable to explain the molecular causes of male infertility when basic sperm parameters are within a normal range and women do not present gynecologic pathology. Consequently, there is a need for accurate diagnostic tools in this area, and microarray technology emerges as promising. We present, for the first time, preliminary results of a comparison of sperm mRNA expression profiles between fertile and infertile men with normal semen parameters, discovering profound discrepancies between groups, with potential diagnostic and therapeutic possibilities. (Fertil Steril (R) 2009; 91:1307-10. (C)2009 by American Society for Reproductive Medicine.)

引用

页码：1307 / 1310

页数：4

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