Polyphenol Extracts from Hibiscus sabdariffa Linnaeus Attenuate Nephropathy in Experimental Type 1 Diabetes

被引：55

作者：

Lee, Wen-Chin ^{[2
,3
]}

Wang, Chau-Jong ^{[1
]}

Chen, Yu-Hsin ^{[1
]}

Hsu, Jen-Dong ^{[4
]}

Cheng, Su-Ya ^{[5
]}

Chen, Hong-Chen ^{[3
]}

Lee, Huei-Jane ^{[1
]}

机构：

[1] Chung Shan Med Univ, Coll Med, Inst Biochem & Biotechnol, Taichung, Taiwan

[2] Show Chwan Mem Hosp, Dept Internal Med, Div Nephrol, Changhua, Taiwan

[3] Natl Chung Hsing Univ, Dept Life Sci, Taichung 40227, Taiwan

[4] Chung Shan Med Univ Hosp, Dept Pathol, Taichung, Taiwan

[5] Chung Shan Med Univ Hosp, Clin Lab, Taichung, Taiwan

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2009年 / 57卷 / 06期

关键词：

Hibiscus sabdariffa L; polyphenols; diabetic nephropathy; oxidative stress; LOW-DENSITY-LIPOPROTEIN; ATHEROSCLEROSIS; PHOSPHORYLATION; CHOLESTEROL; APOPTOSIS; OXIDATION; CELLS; LDL;

D O I：

10.1021/jf802993s

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

Diabetic nephropathy progressed to end-stage renal disease (ESRD) is found in type 1 or type 2 diabetes. Oxidative stress is one of the precipitation factors in diabetic nephropathy. Previously, Hibiscus sabdariffa Linnaeus and its polyphenol extracts were found to possess antioxidative effects. This study is aimed to investigate the effect of Hibiscus sabdariffa L. polyphenol extract (HPE) in streptozotocin (STZ) induced diabetic nephropathy. The results show that HPE reduced kidney mass induced by STZ significantly, as well as improving hydropic change of renal proximal convoluted tubules in the rats. HPE also significantly reduced serum triglyceride, total cholesterol and LDL in STZ induced rats. Treatment with HPE significantly increased the activity of catalase and glutathione and reduced lipid peroxidation (thiobarbituric acid-reactive substances, TBARS). The findings of this research show the beneficial effects of HPE on STZ induced diabetic nephropathy including pathology, serum lipid profile and oxidative marker in kidney.

引用

页码：2206 / 2210

页数：5

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