Amyloid precursor protein secretases as therapeutic targets for traumatic brain injury

被引：202

作者：

Loane, David J. ^{[1
]}

Pocivavsek, Ana ^{[1
]}

Moussa, Charbel E-H ^{[1
]}

Thompson, Rachel ^{[1
]}

Matsuoka, Yasuji ^{[2
]}

Faden, Alan I. ^{[1
]}

Rebeck, G. William ^{[1
]}

Burns, Mark P. ^{[1
]}

机构：

[1] Georgetown Univ, Med Ctr, Dept Neurosci, Washington, DC 20007 USA

[2] Georgetown Univ, Med Ctr, Dept Neurol, Washington, DC 20007 USA

来源：

NATURE MEDICINE | 2009年 / 15卷 / 04期

基金：

美国国家卫生研究院;

关键词：

LONG-TERM ACCUMULATION; ALZHEIMERS-DISEASE; BETA-SECRETASE; HEAD TRAUMA; PRESENILIN-1; MOUSE; EXPRESSION; DEPOSITION; AXONS; INHIBITORS;

D O I：

10.1038/nm.1940

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Amyloid-beta (A beta) peptides, found in Alzheimer's disease brain, accumulate rapidly after traumatic brain injury (TBI) in both humans and animals. Here we show that blocking either beta- or gamma-secretase, enzymes required for production of A beta from amyloid precursor protein (APP), can ameliorate motor and cognitive deficits and reduce cell loss after experimental TBI in mice. Thus, APP secretases are promising targets for treatment of TBI.

引用

页码：377 / 379

页数：3

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