SPARC (osteonectin/BM-40)

被引：108

作者：

Motamed, K ^{[1
]}

机构：

[1] Hope Heart Inst, Dept Vasc Biol, Seattle, WA 98122 USA

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 1999年 / 31卷 / 12期

关键词：

extracellular matrix; angiogenesis; cataracts; tumor growth;

D O I：

10.1016/S1357-2725(99)00090-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

SPARC (Secreted ProteinAcidic and Rich in Cysteine) is a prototype of a family of biologically active glycoproteins that bind to cells and to extracellular matrix (ECM) components. It is expressed spatially and temporally during embryogenesis, tissue remodeling and repair. SPARC is a modular protein (34 kDa) comprised of three structural domains, one or more of which are implicated in the regulation of cell adhesion, proliferation, matrix synthesis/turnover. Rapid proteolysis of SPARC by extracellular proteases accounts for its transient detection in the extracellular environment. The proposed roles of SPARC in the development of cataracts and the regulation of angiogenesis during wound healing and tumor growth account for the recent attention it has received from the biomedical community. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1363 / 1366

页数：4

共 21 条

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