Transcription and the nuclear periphery: edge of darkness?

被引：48

作者：

Deniaud, Emmanuelle ^{[1
]}

Bickmore, Wendy A. ^{[1
]}

机构：

[1] Univ Edinburgh, Inst Genet & Mol Med, MRC Human Genet Unit, Edinburgh EH4 2XU, Midlothian, Scotland

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2009年 / 19卷 / 02期

基金：

英国医学研究理事会;

关键词：

CHROMOSOME TERRITORIES; SPATIAL-ORGANIZATION; EPIGENETIC CONTROL; MAMMALIAN-CELLS; GENE-EXPRESSION; PORE COMPLEX; ARRANGEMENTS; LAMINA; ORDER; REORGANIZATION;

D O I：

10.1016/j.gde.2009.01.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The nuclear periphery has conventionally been considered as a zone of Inactive chromatin and transcriptional repression. Recent studies have shed new light oil the types of sequences associated with proteins of the nuclear periphery in mammalian cells and have investigated the functional significance of artificially locating genes there. The results of these studies reveal a complex picture. Whilst the edge of the nucleus does seem to have a direct effect on the expression of some genes, other genes seem unaffected by their proximity to the nuclear periphery. Moreover, the nuclear periphery itself is heterogeneous, with microdomains of differing compositions, associating with different genomic regions and probably having differential effects oil genome function.

引用

页码：187 / 191

页数：5

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