Cytomegalovirus is not associated with progression and metastasis of colorectal cancer

被引：24

作者：

Knösel, T ^{[1
]}

Schewe, C ^{[1
]}

Dietel, M ^{[1
]}

Petersen, I ^{[1
]}

机构：

[1] Univ Hosp, Charite, D-10098 Berlin, Germany

来源：

CANCER LETTERS | 2004年 / 211卷 / 02期

关键词：

human cytomegalovirus; colorectal cancer; metastases;

D O I：

10.1016/j.canlet.2004.02.011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recently, it was hypothesized that human cytomegalovirus (HCMV) might be associated with colorectal cancer progression. However, the role of HCMV infection in colorectal cancer remains controversial. We aimed to assess whether nucleic acids and/or gene products of HCMV could be detected in primary and metastatic colorectal carcinomas. Fresh-frozen biopsy specimens from 77 primary and metastatic colorectal carcinomas of randomly selected patients were analyzed by PCR and immunohistochemistry. We investigated 57 primary tumors and 20 metastases, comprising 13 tumor pairs from the same patient. In PCR, four primary tumors showed a positive CMV result whereas all investigated metastases were negative including three paired samples from positive primaries. In immunohistochemistry, no specific staining could be determined in all neoplastic epithelial cells. In summary, we think that there is no association between CMV infection and tumor progression or metastasis formation of colorectal cancer. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：243 / 247

页数：5

共 13 条

[1]

[Anonymous], COLORECTAL TUMORS

[2]

DALE DC, 1996, GASTROINTESTINAL CAN, P14

[3] DETECTION OF CYTOMEGALO-VIRUS IN URINE FROM NEWBORNS BY USING POLYMERASE CHAIN-REACTION DNA AMPLIFICATION [J].