Beyond the Null hypothesis - Do the HERS results disprove the estrogen/coronary heart disease hypothesis?

被引：12

作者：

Blumenthal, RS

Zacur, HA

Reis, SE

Post, WS

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Med Cardiol, Baltimore, MD USA

[2] Johns Hopkins Univ, Sch Med, Dept Obstet & Gynecol, Baltimore, MD USA

[3] Univ Pittsburgh, Med Ctr, Cardiovasc Inst, Pittsburgh, PA USA

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2000年 / 85卷 / 08期

关键词：

D O I：

10.1016/S0002-9149(99)00921-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Despite considerable observational data suggesting that hormone replacement therapy (HRT) would prevent cardiovascular events, the Heart and Estrogen/Progestin Replacement Study found no significant benefit for combined HRT in women with coronary heart disease. Potential explanations for the neutral effect of HRT are explored using insights from recent investigations.

引用

页码：1015 / +

页数：4

共 19 条

[1] Medroxyprogesterone acetate antagonizes inhibitory effects of conjugated equine estrogens on coronary artery atherosclerosis
Adams, MR
Register, TC
Golden, DL
Wagner, JD
Williams, JK
[J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1997, 17 (01) : 217 - 221
[2] Anderson G, 1998, CONTROL CLIN TRIALS, V19, P61
[3] Hormone and nonhormone therapy for the maintenance of postmenopausal health: The need for randomized controlled trials of estrogen and raloxifene
Barrett-Connor, E
Wenger, NK
Grady, D
Mosca, L
Collins, P
Kornitzer, M
Cox, DA
Moscarelli, E
Anderson, PW
[J]. JOURNAL OF WOMENS HEALTH, 1998, 7 (07) : 839 - 847
[4] BECKER RS, 1999, ANN INTERN MED, V130, P897
[5] Lack of effect of raloxifene on coronary artery atherosclerosis of postmenopausal monkeys
Clarkson, TB
Anthony, MS
Jerome, CP
[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1998, 83 (03) : 721 - 726
[6] Hormone replacement therapy, inflammation, and hemostasis in elderly women
Cushman, M
Meilahn, EN
Psaty, BM
Kuller, LH
Dobs, AS
Tracy, RP
[J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1999, 19 (04) : 893 - 899
[7] Effect of postmenopausal hormones on inflammation-sensitive proteins - The Postmenopausal Estrogen/Progestin Interventions (PEPI) Study
Cushman, M
Legault, C
Barrett-Connor, E
Stefanick, ML
Kessler, C
Judd, HL
Sakkinen, PA
Tracy, RP
[J]. CIRCULATION, 1999, 100 (07) : 717 - 722
[8] Postmenopausal estrogen and progestin use and the risk of cardiovascular disease
Grodstein, F
Stampfer, MJ
Manson, JE
Colditz, GA
Willett, WC
Rosner, B
Speizer, FE
Hennekens, CH
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1996, 335 (07) : 453 - 461
[9] The HERS trial results: Paradigms lost?
Herrington, DM
[J]. ANNALS OF INTERNAL MEDICINE, 1999, 131 (06) : 463 - 466
[10] Individual and combined effects of estrogen progestin therapy and lovastatin on lipids and flow-mediated vasodilation in postmenopausal women with coronary artery disease
Herrington, DM
Werbel, BL
Riley, WA
Pusser, BE
Morgan, TM
[J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1999, 33 (07) : 2030 - 2037

← 1 2 →