Protein Z influences the prothrombotic phenotype in factor v Leiden patients

被引：64

作者：

Kemkes-Matthes, B ^{[1
]}

Nees, M ^{[1
]}

Kühnel, G ^{[1
]}

Matzdorff, A ^{[1
]}

Matthes, KJ ^{[1
]}

机构：

[1] Univ Giessen, Zentrum Innere Med, D-35385 Giessen, Germany

来源：

THROMBOSIS RESEARCH | 2002年 / 106卷 / 4-5期

关键词：

protein Z; protein Z-dependent protease inhibitor (ZPI); thrombophilia; factor V Leiden mutation;

D O I：

10.1016/S0049-3848(02)00181-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Protein Z enhances the inhibition of factor Xa by protein Z-dependent protease inhibitor (ZPI). Thus, diminution of protein Z should induce prothrombotic tendency due to lowered collactor activity for ZPI. In Factor V Leiden mice, prothrombotic tendency of severe diminution or lack of protein Z was demonstrated. We here present first studies in humans, indicating that diminution of protein Z in factor V Leiden patients aggravates thromboembolic risk. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：183 / 185

页数：3

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