Models of axon guidance and bundling during development

被引:50
作者
Hentschel, HGE
van Ooyen, A [1 ]
机构
[1] Emory Univ, Dept Phys, Atlanta, GA 30322 USA
[2] Netherlands Inst Brain Res, Grad Sch Neurosci, NL-1105 AZ Amsterdam, Netherlands
关键词
axon guidance; fasciculation; chemoattraction; contact attraction; diffusion; neurite outgrowth;
D O I
10.1098/rspb.1999.0913
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Diffusible chemoattractants and chemorepellants, together with contact attraction and repulsion, have been implicated in the establishment of connections between neurons and their targets. Here we study how such diffusible and contact signals can be involved in the whole sequence of events from bundling of axons, guidance of axon bundles towards their targets, to debundling and the final innervation of individual targets. By means of computer simulations, we investigate the strengths and weaknesses of a number of particular mechanisms that have been proposed for these processes.
引用
收藏
页码:2231 / 2238
页数:8
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