Daxx-mediated transcriptional repression of MMP1 gene is reversed by SPOP

被引：18

作者：

La, M

Kim, K

Park, J

Won, J

Lee, JH

Fu, YM

Meadows, GG

Joe, CO ^{[1
]}

机构：

[1] Korea Adv Inst Sci & Technol, Dept Biol Sci, Taejon 305701, South Korea

[2] Chungnam Natl Univ, Sch Med, Dept Dermatol, Taejon 305764, South Korea

[3] Washington State Univ, Canc Prevent & Res Ctr, Dept Pharmaceut Sci, Pullman, WA 99164 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2004年 / 320卷 / 03期

关键词：

Daxx; ETS1; MMP1; scleroderma; SPOP;

D O I：

10.1016/j.bbrc.2004.06.022

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Daxx-mediated transcriptional repression was modulated by a speckled POZ domain protein SPOP which was first identified as an autoantigen from the serum of a scleroderma patient. This is the first report on the biochemical and functional interactions between Daxx and SPOP. The COOH-terminal region of Daxx interacts with the NH2-terminal region of SPOP. SPOP reversed the transcriptional repression mediated by Daxx which binds with ETS1 transcription factor to repress ETS1-responsive gene expression. Mutagenesis study suggests that the ability of SPOP to self-associate as well as its ability to bind with Daxx was important for the modulation of Daxx-mediated transcriptional repression. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：760 / 765

页数：6

共 25 条

[1] THE POZ DOMAIN - A CONSERVED PROTEIN-PROTEIN INTERACTION MOTIF [J].