Effects of L-carnosine on renal sympathetic nerve activity and DOCA-salt hypertension in rats

被引:47
作者
Niijima, A
Okui, T
Matsumura, Y
Yamano, T
Tsuruoka, N
Kiso, Y
Nagai, K
机构
[1] Niigata Univ, Sch Med, Niigata 9518510, Japan
[2] Osaka Univ Pharmaceut Sci, Dept Pharmacol, Takatsuki, Osaka 5691094, Japan
[3] Osaka Univ, Div Prot Metab, Inst Prot Res, Suita, Osaka 5650871, Japan
[4] Suntory Ltd, Inst Hlth Care Sci, Osaka 6180012, Japan
来源
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL | 2002年 / 97卷 / 02期
关键词
blood pressure; hypertension; autonomic nervous system; efferent; leptin;
D O I
10.1016/S1566-0702(02)00048-6
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The effects of L-carnosine (beta-alanyl-L-histidine) on the neural activity of the renal sympathetic nerve and on DOCA-salt hypertension in rats were examined. Intravenous injection of 1 mug L-carnosine inhibited renal sympathetic nerve activity in urethane-anesthetized animals, and a diet containing 0.0001% or 0.001% L-carnosine decreased blood pressure elevation in DOCA-salt hypertensive rats. Since L-carnosine is mainly synthesized in the skeletal muscles of mammals, it is not unreasonable to postulate that L-carnosine is an endogenous factor controlling the blood pressure in a manner possibly antagonistic to the obesity-associated hypertensive effect of leptin. (C) 2002 Elsevier Science B.V All rights reserved.
引用
收藏
页码:99 / 102
页数:4
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