Factors affecting QuickVue Influenza A plus B rapid test performance in the community setting

被引：45

作者：

Cheng, Calvin K. Y. ^{[1
,2
]}

Cowling, Benjamin J. ^{[1
,2
]}

Chan, Kwok Hung ^{[3
]}

Fang, Vicky J. ^{[1
,2
]}

Seto, Wing Hong ^{[4
]}

Yung, Raymond ^{[5
]}

Uyeki, Timothy M. ^{[6
]}

Houck, Peter M. ^{[7
]}

Peiris, J. S. Malik ^{[3
]}

Leung, Gabriel M. ^{[1
,2
]}

机构：

[1] Univ Hong Kong, Dept Community Med, Hong Kong, Hong Kong, Peoples R China

[2] Univ Hong Kong, Sch Publ Hlth, Hong Kong, Hong Kong, Peoples R China

[3] Univ Hong Kong, Dept Microbiol, Hong Kong, Hong Kong, Peoples R China

[4] Hosp Author, Queen Mary Hosp, Dept Microbiol, Hong Kong, Hong Kong, Peoples R China

[5] Govt Hong Kong SAR, Dept Hlth, Ctr Hlth Protect, Hong Kong, Hong Kong, Peoples R China

[6] Ctr Dis Control & Prevent, Influenza Div, NCPDCID, Atlanta, GA 30333 USA

[7] CDC, Seattle Quarantine Stn, Div Global Migrat & Quarantine, NCPDCID, Seattle, WA 98158 USA

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2009年 / 65卷 / 01期

关键词：

Human influenza; Immunoassay; Diagnostic tests; Sensitivity; Specificity; Viral load; REVERSE TRANSCRIPTION-PCR; VIRAL CULTURE; RESPIRATORY VIRUSES; DIAGNOSIS; CHILDREN; ACCURACY; IMMUNOASSAY; INFECTIONS; PATTERNS; SWABS;

D O I：

10.1016/j.diagmicrobio.2009.05.003

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Rapid diagnosis of influenza can facilitate timely clinical management. We evaluated the performance of the QuickVue Influenza A + B test (Quidel, San Diego, CA) in a community setting and investigated the factors affecting test sensitivity. We recruited 1008 subjects from 30 outpatient clinics in Hong Kong between February and September 2007. Each subject provided 2 pooled pairs of nose and throat swabs; 1 pair was tested by the QuickVue rapid test on site, and the other pair was sent to a laboratory for reference tests. Among 998 enrolled subjects with valid results, the rapid test had overall sensitivity of 0.68 and specificity of 0.96 compared with viral culture. Sensitivity for both influenza A and B was significantly higher for specimens with viral loads greater than 5 log(10) copies/mL. The QuickVue Influenza A + B test has similar sensitivity in point-of-care community settings to more controlled conditions. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：35 / 41

页数：7

共 29 条

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