Ellagic acid derivatives and cytotoxic cucurbitacins from Elaeocarpus mastersii

被引：36

作者：

Ito, A

Chai, HB

Lee, D

Kardono, LBS

Riswan, S

Farnsworth, NR

Cordell, GA

Pezzuto, JM

Kinghorn, AD ^{[1
]}

机构：

[1] Univ Illinois, Coll Pharm, Program Collaborat Res Pharmaceut Sci, Chicago, IL 60612 USA

[2] Univ Illinois, Coll Pharm, Dept Med Chem & Pharmacognosy, Chicago, IL 60612 USA

[3] Indonesian Inst Sci, Tangerang 15310, Indonesia

[4] Indonesian Inst Sci, Res & Dev Ctr Biol, Herbarium Bogoriense, Bogor 16122, Indonesia

来源：

PHYTOCHEMISTRY | 2002年 / 61卷 / 02期

关键词：

Elaeocarpus mastersii; Elaeocarpaceae; cytotoxicity; ellagic acid derivatives; cucurbitacins;

D O I：

10.1016/S0031-9422(02)00232-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bioassay-guided investigation of the bark of Elaeocarpus mastersii using KB (human oral epidermoid carcinoma) cells as a monitor led to the isolation of two cucurbitacins, cucurbitacin D and cucurbitacin F as cytotoxic principles, together with two ellagic acid derivatives, 4'-O-methylellagic acid 3-(2",3"-di-O-acetyl)-alpha-L-rhamnoside (1) and 4,4'-O-dimethylellagic acid 3-(2",3"-di-O-acetyl)-alpha-L-rhamnoside (2). These compounds were evaluated against a panel of human tumor cell lines. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：171 / 174

页数：4

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